Frances McDormand stars as Jane a successful dress designer who has taken to wild public outbursts stops washing her hair and is married to a kind man who might be gay (Simon McBurney). Joan Cusack is Franny a multimillionaire who appears to have the perfect life with her husband (Greg Germann) and kids. Catherine Keener plays Christine who is building her dream house and writing a screenplay with her husband (Jason Isaacs) as their life together is crumbling. And the youngest of the foursome Olivia (Jennifer Aniston) is a pot-smoking ne'er-do-well who works as a maid stalks her ex-lover and has a thing about not paying for certain high-end cosmetics. As they prepare to attend a major fundraiser for ALS they all take stock of their lives reaching some very difficult conclusions...