Kilt-wearing American Elmo McElroy (Samuel L. Jackson) an illegal drug chemist travels to Liverpool hoping to find a market for his new designer drug (which is supposed to be 51 times more effective than cocaine hence the title) after double-crossing drug dealer The Lizard (Meat Loaf) back in L.A. This is McElroy's last big deal before he retires and he plans to sell the drug to another crime boss Durant (Ricky Tomlinson) for $20 million but his chaperone and guide to the Liverpo