While attending a fundraising gala Sarah Jordan (Jolie) a naive married American socialite living in England witnesses a fiery plea delivered by an intruder renegade humanitarian Dr. Nick Callahan (Clive Owen). His plea made on behalf of impoverished African children under his care turns Sarah's life upside down. Attracted to Nick and his cause she impulsively abandons her sheltered life in England to work along side him in his effort to aid the helpless and anguished victims.